Comedic legend Garry Shandling has died of a heart attack at the age of 66. He was rushed to an L.A. hospital Thursday morning from his home after suffering a massive heart attack, according to sources close to the actor.

Shandling is best known for his show It’s Garry Shandling’s Show (1986-1990) and The Larry Sanders Show (1992-1998). Movie fans would have seen him most recently as Senator Stern in Iron Man 2 and Captain America: The Winter Soldier, the latter now listed as his last acting credit.

 

 

Several prominent celebrities immediately responded via Twitter:

 

Images and video via Marvel (Walt Disney Studios)